Highlights

• Excellence in Surface Science Award
  
• Student Town Hall Meeting
  • The Place where technical students can “meet the industry” during a luncheon. This Q&A plus networking session is a successful introduction for students to industry perspectives.
• Student Poster Award competition (Students: submit a poster and receive FREE admission to the symposium!)
• Lively debate session
• Great networking opportunities
• You will be enriched by the science, by our debate session and by our unique blend of industry, academic, regulatory and clinical attendees.

Hotel Information

Loews Atlanta Hotel
1065 Peachtree Street
Atlanta, Georgia 30309
About the hotel

The room block for The Surfaces in Biomaterials Foundation is available for guests to book reservations online using the Group Code: SIBO17

Go to www.LoewsHotels.com/Atlanta. You will be directed to the property's home page with the code already entered in the appropriate field. All you need to do is enter your arrival date to begin the reservation process.

Single/Double rooms: $159

Reservations are to be made by the individual online or through the Loews’ reservation department at: (404) 745-5000. Make sure to ask for the Surfaces in Biomaterials Foundation rate in order to receive the special group rate. Reserve your room by September 17, 2010 to receive the group rate.

Any cancellations or changes must be made at least 24 hours prior to the arrival date.

Please contact Ashley Crunstedt: ashleyc@surfaces.org with any questions

About the hotel:
Centrally located in midtown Atlanta, there are plenty of nearby attractions to keep you busy:

• Piedmont Park
  
• Atlanta Botanical Gardens
  
• World of Coca-Cola
  
• Georgia Aquarium
  
• Centennial Olympic Park
  
• Zoo Atlanta
  
• Six Flags over Georgia
  
• Stone Mountain Park
  
• Fernbank Museum of Natural History
  
• The King Center
  
• Jimmy Carter Presidential Library
  
• Atlanta History Center
  
• Atlanta Cyclorama/Civil War Museum
  
• High Museum of Art
  
• Museum of Design Atlanta
  
• And many more!

Click here for more information on presentations or to download a registration form.

Loews Atlanta Hotel

7:00–8:25 a.m.

7:20–8:20 a.m

8:20–8:25 a.m.

Registration and Breakfast

General Poster Session and Student Poster Judging
Co-chairs: Carl Turnquist, Kristen Cardinal
Judges: Gene Boland, Carl Turnquist, Rob Kellar

President’s Welcome

8:25–8:45 a.m.

8:45–9:30 a.m.

9:30–10:00 a.m.

10:00–10:30 a.m.

Session 1 Poster session

Break

10:30–11:00 a.m.

Invited Speaker: David Grainger, University of Utah
“Protein Sorting on to Patterned Surfaces”

Jens Thies, DSM Biomedical
“DSM Non-Biofouling Coatings: A Stealth Approach to the Fighting Biofilms”

Robert Ward, DSM PTG, Part of DSM Biomedical
“Biomaterials In a New Role: Treatment and Prevention of Infectious Disease”

Claire Kavanagh, Martin Murphy, Aziz Tnibar, Jonathan Thompson
“In Vivo Antibiotic Release Profile from an Antibiotic Coated Orthopaedic Implant ”

12:00–12:50 p.m.

12:50–1:30 p.m.

Student Town Hall Meeting and Attendee Luncheon
Co-chairs: Vicky Carr-Brendel, Rob Kellar

Surfaces in Biomaterials Foundation Business Meeting

1:30–2:00 p.m.

2:00–3:00 p.m.

Invited Speaker: Conrado Aparicio, PhD, University of Minnesota
“Contact Angles at the Macro- and Micro- Level for Assessing Wettability and Surface Free Energy of Dental Biomaterials”

Puneet Gill, Florida International University
“The Effect of Surface Treatment and Manufacturing Techniques on Ti-Ta Alloy”

3:00–3:30 p.m.

Break

Applied Technology Workshops
Chair: Peg Palmer

3:30–4:00 p.m.

PVA Tepla
“Plasma Surface Modification for Lifescience Applications: A Technology Review”

BASF
“Silver-Based Antimicrobial Technology for Plastic Devices”

4:00–4:30 p.m.

Anasys
“Transition Temperature Microscopy: Nanoscale Thermal Analysis Technique”

SJTRI
“Biochemical Markers in Pre-Clinical Studies”

4:30–5:30 p.m.

5:30 - 6:30 p.m.

BioInterface & Petit Institute for Bioengineering and Bioscience (IBB) Workshop: New Frontiers in Biosurface Applications
Co-chairs: Barbara Boyan, Andrés Garcia, Peter Maziarz

7:00–8:00 a.m.

Pre-Registration and Continental Breakfast

8:00–8:15 a.m.

Welcome and Introduction

8:15–9:00 a.m.

9:00–9:45 a.m.

Workshop Speaker 1: Julia Babensee, Georgia Tech, Biomedical Engineering
Topic: Biomaterial/Glycan Cell Interactions

Workshop Speaker 2: Valeria Milam, Georgia Tech, Materials Science
Topic: Employing Double-Stranded Probes on Colloidal Particles for Nucleic Acid Detection

9:45–10:15 a.m.

Break

10:15–11:00 a.m.

Workshop Speaker 3: Andrew Lyon, Georgia Tech, Chemistry & Biochemistry
Topic: Dynamic, Self-Healing, and Nanostructured Hydrogel Coatings

11:00–11:45 a.m.

Workshop Speaker 4: Ken Sandhage, Georgia Tech, Materials Science
Topic: Shape-Preserving, Chemical Tailoring of Nanostructured Assemblies

11:45 a.m.–12:45 p.m.

Lunch & Nanotechnology Research Center Tours

12:45–1:30 p.m.


1:30–2:15 p.m.

Workshop Speaker 5: David Grainger, University of Utah, College of Pharmacy Topic: New Approaches to Analyze DNA and Proteins Immobilized at Surfaces

Workshop Speaker 6: James Bryers, University of Washington, Bioengineering Topic: Biofilm Infections and Biomaterials

Panel Discussion
Topic: Converting Academic Insight into Industrial Application

IBB Industrial Partners Program Welcome Reception

IBB Industrial Partners Program Welcome Dinner
Guest Speaker: Dr. Gail Cassell, Vice President, Scientific Affairs and Distinguished Lilly Research Scholar for Infectious Diseases Eli Lilly and Company

Parker H. Petit Institute for Bioengineering and Bioscience Industrial Partners Program

Josiah N. “Cy” Wilcox, Ph.D.
Vice President Science & Technology
Medtronic CardioVascular

Importance of Polymer Biocompatibility for Drug Eluting Stent (DES) Outcomes
The first-generation sirolimus SES) - and paclitaxel- (PES) and the second generation everolimus-eluting stents (EES) have been associated with a higher incidence of late stent thrombosis (LST), particularly beyond the first year after stenting. A similar risk for LST has not been seen with a zotarolimus-eluting stent (ZES). Since these DES all utilize different biostable polymers which remain associated with the metal stent after drug release, we hypothesized that polymer biocompatibility may in part explain differences in rates of LST.

Surface properties of different DES polymers were evaluated to determine their relative hydrophobicity or hydrophilicity. Polymer biocompatibility was evaluated in novel in-vitro assay systems in which endothelial cells, smooth muscle cells and activated monocytes were exposed to different DES polymers coated on 96 well plates. Additional in vivo studies were conducted with bare metal stents (BMS) and commercial DES to evaluate local inflammatory reactions, gene expression and endothelial function in response to acetylcholine stress in porcine coronary arteries.

We observed a consistent correlation between polymer hydrophobicity and inflammatory responses both in vitro and in vivo; the more hydrophobic polymers (used in EES, SES and PES) induced increased monocyte binding, superoxide formation, and expression of inflammatory and pro-coagulant genes like tissue factor (TF) in vitro, while the hydrophilic DES polymers, phosphorylcholine (PC) or BioLinx utilized on ZES, show minimal inflammatory responses. Additional studies suggested that DES utilizing hydrophobic polymer surfaces may contribute to increased inflammation and endothelial dysfunction after stenting and are associated with a loss of eNOS and NO production and increases in superoxide production compared to ZES utilizing hydrophilic polymer surfaces.

Overall, these findings suggest the importance of polymer hydrophilicity for biocompatibility, long term safety and efficacy of DES.

Dr. Josiah N. “Cy” Wilcox is currently Vice President and Resident Scholar of Science & Technology at Medtronic CardioVascular in Santa Rosa and directs an interdisciplinary R&D group with responsibility for polymer chemistry, drug screening, next generation DES development and new vascular cell biology initiatives. Dr. Wilcox has been with Medtronic Vascular since July 2003 joining first as a full time consultant while on sabbatical from his position at Emory University. He received his Ph.D. from Rutgers University in 1982 followed by postdoctoral training at Columbia P&S. Dr. Wilcox was previously employed by Genentech (1985-1990) before joining the faculty at Emory University School of Medicine (1990-2004). While at Emory Dr. Wilcox did research in the area of cardiovascular disease, angioplasty restenosis and vascular brachytherapy. He has served on a number of peer review panels at the National Institutes of Health and American Heart Association and is the author of over 100 original research manuscripts. While at Medtronic, Dr. Wilcox has worked closely on the development of the Endeavor stent and led the research team that developed the Resolute drug eluting stent.